RESOURCES
PRESS RELEASE
Metalytics, the Leading Provider of Metabolic Flux Analysis Services to the Life Science Sector, Introduces FirstCHOiceMFA™, a Powerful and Cost-effective Method for Improving CHO Productivity
Research Triangle Park, NC
June 2, 2021
PROJECT ANNOUNCEMENT
Use of Metabolic Flux Analysis (MFA) to Expedite Media Selection and Optimization of CHO
Metalytics and MilliporeSigma
PRESS RELEASE
The National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) Announces New Projects to Advance Biopharmaceutical Manufacturing
Newark, DE
January 9, 2018
PROJECT ANNOUNCEMENT
A Multiscale Metabolic Model for Fed-batch Culture Process Control
Metalytics, Merck, MilliporeSigma, and University of Minnesota
Press & Projects
Presentations
Poster Presentation to NIIMBL 2021 Annual Meeting
Washington, DC and Online; July 14-16, 2021
click on image above for link to full poster presentation
Presentation to Bioprocessing Summit Europe 2021
Online Conference; March 16-17, 2021
click on image above for narrated presentation
Presentation to BioProcessing International 2020
Online Conference; September 21-25, 2020
click on image above for narrated presentation
Select Publications
Metabolic flux analysis has been utilized with a wide variety of organisms for a multitude of research, development and manufacturing applications, from cell line engineering and culture media optimization, to better understanding cancer cell biology and metabolic diseases. Below is a select list of publications from Metalytics’ Founder and Chief Scientific Officer, Dr. Jamey Young, a complete list of publications can be found here.
Application of 13C Flux Analysis to Identify High-Productivity CHO Metabolic Phenotypes
- Metabolic Engineering, 2017
13C Flux Analysis in Biotechnology and Medicine
- Systems Biology, 2017
Application of Isotope Labeling Experiments and 13C Flux Analysis to Enable Rational Pathway Engineering
- Current Opinion in Biotechnology, 2015
13C Metabolic Flux Analysis of Recombinant Expression Hosts
- Current Opinion in Biotechnology, 2014
The Impact of Anti-apoptotic Gene Bcl-2 Expression on CHO Central Metabolism
- Metabolic Engineering, 2014
Role of CHO Central Carbon Metabolism in Controlling the Quality of Secreted Biotherapeutic Proteins
- Pharmaceutical Bioprocessing, 2014
Metabolic Flux Rewiring in Mammalian Cell Cultures
- Current Opinion in Biotechnology, 2013
Peak Antibody Production is Associated with Increased Oxidative Metabolism in an Industrially Relevant Fed-batch CHO Cell Culture
- Biotechnology and Bioengineering, 2013
Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer
- Molecular and Cellular Proteomics, 2016
Mapping Cancer Cell Metabolism with 13C Flux Analysis: Recent Progress and Future Challenges
- Journal of Carcinogenesis, 2013
Mass Spectrometry-based Microassay of 2H and 13C Plasma Glucose Labeling to Quantify Liver Metabolic Fluxes in vivo
- American Journal of Physiology, 2015
Tracking Cellular Metabolomics in Lipoapoptosis- and Steatosis-developing Liver Cells
- Molecular BioSystems, 2011