Keyboard and Mouse

NIIMBL Announces New Projects to Advance Biopharmaceutical Manufacturing
Newark, Del., January 9, 2018

Use of Metabolic Flux Analysis (MFA) to Expedite Media Selection and Optimization of CHO

Metalytics and MilliporeSigma

A Multiscale Metabolic Model for Fed-batch Culture Process Control

Metalytics, Merck, MilliporeSigma, and University of Minnesota


Press & Projects



Presentation to BioProcessing International 2020

Online Virtual Conference

September 21-25, 2020

Presentation to Bioprocessing Summit Europe 2021

Online Virtual Conference

March 16-17, 2021

Select Publications

Metabolic flux analysis has been utilized with a wide variety of organisms for a multitude of research, development and manufacturing applications, from cell line engineering and culture media optimization, to better understanding cancer cell biology and metabolic diseases.  Below is a select list of publications from Metalytics’ Founder and Chief Scientific Officer, Dr. Jamey Young, a complete list of publications can be found here.


Application of 13C Flux Analysis to Identify High-Productivity CHO Metabolic Phenotypes

- Metabolic Engineering, 2017

13C Flux Analysis in Biotechnology and Medicine

- Systems Biology, 2017

Application of Isotope Labeling Experiments and 13C Flux Analysis to Enable Rational Pathway Engineering

- Current Opinion in Biotechnology, 2015

13C Metabolic Flux Analysis of Recombinant Expression Hosts

- Current Opinion in Biotechnology, 2014

The Impact of Anti-apoptotic Gene Bcl-2 Expression on CHO Central Metabolism

- Metabolic Engineering, 2014

Role of CHO Central Carbon Metabolism in Controlling the Quality of Secreted Biotherapeutic Proteins

- Pharmaceutical Bioprocessing, 2014

Metabolic Flux Rewiring in Mammalian Cell Cultures

- Current Opinion in Biotechnology, 2013

Peak Antibody Production is Associated with Increased Oxidative Metabolism in an Industrially Relevant Fed-batch CHO Cell Culture

- Biotechnology and Bioengineering, 2013

Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer

- Molecular and Cellular Proteomics, 2016

Mapping Cancer Cell Metabolism with 13C Flux Analysis: Recent Progress and Future Challenges

- Journal of Carcinogenesis, 2013

Mass Spectrometry-based Microassay of 2H and 13C Plasma Glucose Labeling to Quantify Liver Metabolic Fluxes in vivo

- American Journal of Physiology, 2015

Tracking Cellular Metabolomics in Lipoapoptosis- and Steatosis-developing Liver Cells

- Molecular BioSystems, 2011



Bioprocessing Summit Europe

March 16-17, 2021
Virtual Online Conference

BIO International Convention

June 10-18, 2021

Virtual Online Conference

BioProcess International - US West

March 29-31, 2021
Virtual Online Conference

Bioprocessing Summit

August 16-19, 2021

Sheraton Boston (MA) & Online