VISUALIZING METABOLISM, PROVIDING ACTIONABLE RESULTS
Metalytics specializes in mapping metabolic reaction rates in a wide variety of cell lines and organisms used to produce a myriad of products across various life science industries. We are committed to delivering unparalleled in vitro and in vivo metabolic flux analysis and providing actionable results that will accelerate research, development, and manufacturing timelines.
OPTIONS FOR ANY CELLULAR FACTORY
CoreMFA™ goes beyond traditional metabolomics studies to customize and tailor each individual project, solving difficult problems by identifying specific opportunities for culture and process improvements, leading to increased product quality, quantity, and consistency.
FirstCHOiceMFA™ is a streamlined and cost-effective method for gaining insight into Chinese Hamster Ovary (CHO) cellular metabolism and protein expression, improving CHO performance and productivity.
BEYOND METABOLOMICS
Traditional metabolomics studies are useful, but they are a static list of metabolites, a snapshot in time. If metabolomics can be considered a road map, metabolic flux analysis (MFA) is real-time traffic flow, identifying bottlenecks that constrain cellular growth and productivity. Our CoreMFA platform is dynamic, comprehensive, and quantitative - providing actionable results and enabling further scenario analyses. Metabolomics can help you generate hypotheses, CoreMFA allows you to test those hypotheses and make tangible, significant process improvements.
WHAT WE DO
Metabolic flux analysis mathematically models metabolic pathways and pinpoints nodes and bottlenecks that constrain cellular growth and production. Genetic engineering techniques and/or culture media optimization can then be used to modify the pathway in order to relieve these constraints. By using our CoreMFA platform, companies can drastically reduce analysis complexity, accelerate their understanding of the metabolic processes involved in their cell factories, and more quickly and rationally improve both the quality and quantity of end products.
We Give You a Competitive Advantage
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Increased production capacity & efficiency
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Engineered cell lines
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Optimized culture media
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Reduced raw material costs
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Accelerated time to market
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Increased ROI and profitability
We Optimize and Accelerate Your Bioprocessing Research, Development, and Manufacturing
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Modeling metabolic reaction rates in cell factories
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Deploying metabolic flux analysis with advanced, proprietary software systems
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Accelerating R&D and process improvements
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Improving efficiency and productivity
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Solving complex production issues
We explore your challenges, identify desired outcomes, and develop a plan of action.
You simply send us your samples. We'll generate flux data and maps, provide data analysis and
interpretation, and produce actionable results that will inform and prioritize your next steps.
We provide detailed protocols customized to your cell line and culture conditions.
“We use yeast and E.coli to manufacture commodities and specialty chemicals.
We wanted to know the metabolic flux and tried 7 different approaches, but Metalytics’ technology was the best thing for understanding what was going on.”
Dr. Joshua Lerman, Amyris
“This work demonstrates the usefulness of MFA for identifying optimal media for cells.
Success in using these MFA models for clonal grouping and other diagnostic media identification strategies can greatly reduce the timeline and resources needed to optimize media for CHO cells.”
Dr. Jeremiah Riesberg, MilliporeSigma